- Siler Family Papers, 1848/19681,158
- Long/Trail Southeastern West Virginia Historical Records, 1870/2025620
- W. Jett Lauck papers, 1900/1952449
- Gregory A. Prince Mormon Studies Collection, 1813/2020406
- Philip S. Hench Walter Reed Yellow Fever collection, 1800/1998, bulk 1863/1974370
- The University of Virginia Anatomy Laboratory Lantern Slides collection, 1920/1965325
- Edward L. Stone/Borderland Coal Company Papers
1895-1937320
- Carter Glass Papers, 1820/1946306
- Papers of the Low Moor Iron Company
1873-1927300
- duPont family papers, 1767/1982264
- Samuel Davis Stokes Papers, 1915/1925227
- Fries Textile Plant Records, 1900/1988226
- G. Walter Mapp Papers, 1873/1941219
- Bailey-Law Collection, 1825/1971201
- Farrier Family Papers, 1894/1972196