- Charles T. Smith photographs, 1880/2007, bulk 1990/199917
- Chesapeake Western Railway Company Records, 1916/19823
- Christine Hoepfner Collection on the Shenandoah National Park, 1911/20003
- Civil War Miscellaneous Collection, 1860/2005, bulk 1862/19287
- Class of 1913 Reunion Book, 1914/19352
- Cleveland Family Papers, 1880/19585
- Cross Keys Precinct voting records, 1902/19605
- Daisy Bacon Papers, 1857/198617
- Davis, Kline, and Hutton Family papers, 1816/197713
- Department of Living Sciences records, 1915/20033
- Diplomas, 1912/19412
- Dudley and Rexrode Family Papers, 1873/200510
- Eldon Bowman collection of Bowman family papers, 1797/201915
- Elizabeth A. Wenger Papers, 1884/19512
- Elmer Lewis Smith Papers, 1900/19811