- Cleaver Family Papers, 1777/19691
- Fleming Family Papers, 1810/19431
- Hiram Carpenter, Records of a Pleasants County Businessman, 1914/1980, bulk 1918/19661
- McNeill Family Papers, 1770/19291
- Ohio River Sheet Music and Other Material, 1845/19861
- Ohio Valley Floods Papers, 1913/19711
- Roy Thistle, Collector, Scrapbook regarding Ohio River History, 1855/19341
- Steamboats Records, 1877/19391
- Thomas Browse Family Papers, 1785/1942, bulk 1830/19101
- U.S. Army Corps of Engineers, Photographs of Operations in Pennsylvania, Ohio, New York, and the Pacific Northwest, 1914/19191
- Woodbridge-Blennerhassett Papers, 1797/19351