- Adolphus DeBussey, Soldier, Civil War Letters, 1861/1998, bulk 1861/18711
- Alan Clarke Railroad Research Papers, 1861/20123
- Albert Blakeslee White (1856-1941) Papers, 1888/19291
- Allen Family Papers, 1766/19333
- Ancella Bickley, Historian, Research Papers regarding African-Americans, 1775/2018, bulk 1970/20116
- Appalachian Prints Collection, 1839/2010, bulk 1859/19092
- Archibald W. Campbell (1839-1899), Newspaperman, Papers, 1855/1941, bulk 1855/18991
- Arthur I. Boreman Papers, 1830/19491
- Asa Orin Bishop Papers, 1910/19901
- Atkeson-Morgan Family Papers, 1833/1923, bulk 1850/19002
- Barbara Howe, History Professor, Research Papers regarding the History of the College of Arts and Sciences, 1870/2005, bulk 1990/20052
- Barnette Collection, Lawyer, Businessman, Educator, Philanthropist, and Chairman Emeritus of Bethlehem Steel Corporation, 1905/20201
- Braxton County (W. Va.) Court Records and Miscellaneous Papers, 1830/19532
- Capt. William Sommerville (1756-1826) Papers, 1799/18881
- Carl Robinson, Soldier, Photographs from Post-World War I AEF Military Tour in France and Other Material, 1919/19412