- Bethlehem Stone Church Records, 1844/20114
- Bettie Hiter Willis Papers, 1864/19421
- Blackley Family papers, 1830/20206
- Catlett Family Papers, 1850/1933, bulk 1901/19292
- Charles Grattan Price Jr. and Don W. Thomas collection on the Chesapeake Western Railway, 1872/19964
- Charles Grattan Price Jr. collection on Tweetsie and the Shenandoah Central Railroad, 1916/1997, bulk 1948/19561
- Chesapeake Western Railway Company Records, 1916/19821
- Christine Hoepfner Collection on the Shenandoah National Park, 1911/20001
- Civil War Miscellaneous Collection, 1860/2005, bulk 1862/19284
- Daisy Bacon Papers, 1857/19864
- Davis, Kline, and Hutton Family papers, 1816/19774
- Department of Living Sciences records, 1915/20031
- Dudley and Rexrode Family Papers, 1873/20052
- Eldon Bowman collection of Bowman family papers, 1797/20194
- Ernest M. Dickerman papers, 1904/20051