- Adolphus P. Howard Papers, 1850/19381
- Lewis Family Papers, 1825/19361
- McNeill Family Papers, 1770/19291
- Midwest commercial architecture photograph collection, 1900/19201
- Minnie Kendall Lowther Papers, 1907/19451
- Nat T. Frame (1877-1948) Papers, 1914/19481
- Roy Bird Cook, Collector, Papers regarding the Civil War in Southern West Virginia, 1844/1938, bulk 1861/18671
- Roy Thistle, Collector, Scrapbook regarding Ohio River History, 1855/19341
- Talbott-Tolbert Family Papers, 1784/19311
- U.S. Army Corps of Engineers, Photographs of Operations in Pennsylvania, Ohio, New York, and the Pacific Northwest, 1914/19191
- William McCleery (1741-1821) Papers, 1770/1945, bulk 1770/18571
- Wilson-Lewis Family Papers, 1693/19421