- Abraham Lincoln Collection, 1860/19651
- Administration records collection, 1776/19761
- Advertisement Trade Card for "Quignon-Rombach", 1880/19201
- African American Family photograph album, 1910/19601
- African and African American photograph collection, 1850/19451
- Alan R. Shirkey photograph collection, 1877/19171
- Alexander Sterrett Paxton Papers, 1858/1959, bulk 1861/18651
- Alexander, Fultz, and Willson Families Collection, 1770/19701
- Alphin Family Photographs, 1870/19301
- An interior view of Washington and Lee University's Lewis Brooks Museum, 1905/19201
- Anderson Family papers, 1755/19581
- Ann Smith Academy Papers, 1807/19101
- Anne McClung Collection, 1844/19661
- Baer Family Papers, 1744/19291
- Bank of Rockbridge collection, 1862/19131