- Charlton Family Papers, 1853/19582
- Chilhowie Milling Company Correspondence, 1902/19173
- Christian Hook Diary, 1864/19251
- Christiansburg [Virginia] Industrial Institute Historical Documents, 1866/19916
- Civil War Scrapbook, 1864/19162
- Civil War Small Manuscripts Collection, 1861/19962
- Clarence Paul Miles Academic Regalia, 1902/19601
- Clarence Paul Miles Papers, 1902/19604
- Claudius Lee Papers, 1887/19544
- Clifford-Wysor Collection, 1852/19584
- College of Agriculture and Life Sciences (CALS) Collection,, 1900/20011
- Craft Family Collection,, 1861/19191
- Creed F. Flanary Account Books, 1871/19083
- Croy Family Papers, 1859/19388
- Daisy Starbird Manuscript Cookbook, 19051