- Bell, Kent, Cloyd, Withrow Family Collection, 1780/199831
- Benjamin Huddle Diary, 1861/20062
- Bert T. Wilson Papers,, 1889/19263
- Bigler-Sessler-John Family Papers, 1752/19251
- Black, Kent, and Apperson Family Papers, 1779/198424
- Blacksburg Baptist Church Records, 1894/200711
- Blacksburg [Virginia] Odd Fellows Records, 1902/19692
- Blacksburg [Virginia] Presbyterian Church Land Deeds, 1850/19242
- Blake W. Corson, Jr., Papers, 1861/1984, bulk 1934/19792
- Blue Ridge Springs Correspondence, 1895/19422
- Bobbitt Family Papers, 1825/19512
- Brown Family Papers, 1825/1965, bulk 1850/18941
- Buckhorn Coal Company Records, 1880/19614
- Burns & Burns Records, 1871/191022
- C. B. Anderson Records, 1884/19102