- Henry H. Hill Collection, 1893/19631
- Historical Maps Collection, 1500/20231
- Independent Order of St. Luke Records, 1877/19701
- J.H. Slusser & Son Store Ledger, 1902/19091
- John R. Hutcheson Family Collection, 1890/1969, bulk 1930/19501
- Joseph F. Ware Collection, 1900/1971, bulk 1915/19201
- Louis O'Shaughnessy Letters, 1903/19051
- Map of Montgomery County Virginia. Mountains, Streams, Towns, Roads, Coal, Property Owners, etc, etc, By W.F. Wall, Engineer Assisted by Harry A. Wall., 1890/19251
- Ralph Minthorne Brown Papers, 1872/19471
- Rosanna Croy Dawson Collection, 1847/19071
- Shell Family Papers, 1871/19321
- Sullivan Family Papers, 1800/19571
- Town of Blacksburg, [Virginia], Collection, 1885/19681
- United Daughters of the Confederacy, Dr. Harvy Black Chapter Records, 1862/20101
- Virginia Hummel Papers, 1830/19981