- S. B. Barham Account Book, 1896/19151
- S. Corder Musgrave Papers, 1891/19661
- S. F. (Bill) Royall, Jr. papers, 1883/19791
- S. George Company Records, 1900/19751
- S. Maria Elliott Family Collection, 1826/19421
- S.A. Thompson Family Papers, 1899/19303
- Sabra Lucinda (Miner) Sturgiss Papers, 1838/19091
- Sadie Heath Cabaniss Letters, 1900/19041
- Saint Andrew's Society collection, 1861/19956
- Salem School District, Board of Education, Record Books, 1888/19201
- Sallie Bennett Papers regarding World War I Flying Ace Louis Bennett, Jr., 1873/2009, bulk 1904/19264
- Sallie Maxwell Bennett, Artist, Photograph Album, 19021
- Salt Sulphur Springs Records, 1819/19321
- Salt Sulphur Springs Records, 1894/19041
- Sam Bowman Papers, 1848/19672