- Papers of the Low Moor Iron Company
1873-192771
- J. Hoge Tyler Family Collection, 1802/195624
- Austin-Twyman Papers, 1765/193919
- Geo. Gregory Smart collection of Washington and Mount Vernon ephemera, 1793/201715
- James Washington Singleton Papers, 1770/1975, bulk 1850/192015
- International Association for Identification Records, 1842/2012, bulk 1910/195912
- Richard Wright collection, 1806/201712
- Robert Morton Hughes Papers, 1754/195012
- Ancella Bickley, Historian, Research Papers regarding African-Americans, 1775/2018, bulk 1970/201111
- Charles Willis Cassell Family Papers, 1883/195011
- Virginia Tech and Local History Mounted Clippings10
- Henry Denison Cole Papers, 1786/19399
- Paulett Family Business Records, 1877/19299
- Black, Kent, and Apperson Family Papers, 1779/19848
- Blacksburg Baptist Church Records, 1894/20077