- Oren F. Morton (1857-1926) Papers, 1799/192645
- Grigsby-Galt Papers, 1736/1982, bulk 1840/193044
- Monongalia County Historical Records, 1792/1982, bulk 1878/197644
- Fries Textile Plant Records, 1900/198843
- Charles Willis Cassell Family Papers, 1883/195042
- Papers of Mark Twain
1862-1946, bulk 1872-191041
- James Washington Singleton Papers, 1770/1975, bulk 1850/192040
- W.E. Bibb Papers
1830-194040
- William Carter Stubbs Papers (I), 1832/193640
- Map Collection, 1629/199139
- Papers of the Mount Vernon Ladies' Association, 1858/201639
- Austin-Twyman Papers, 1765/193938
- Writers' Program in West Virginia Records, 1850/1942, bulk 1935/194238
- McHone Brothers (LLC) Collection of Houck Tannery Records, 1870/191337
- West Virginia University, Agricultural Experiment Station, Records, 1885/198837