- Duke Family Papers
1764-198361
- Storer College Correspondence, Business Papers and Other Material, 1854/196458
- Thomas Browse Family Papers, 1785/1942, bulk 1830/191055
- Aubrey E. Strode papers, 1861/196953
- Papers of Mark Twain
1862-1946, bulk 1872-191052
- Snyder Family papers, 1850/190149
- William and Mary Quarterly Records, 1893/194349
- Ancella Bickley, Historian, Research Papers regarding African-Americans, 1775/2018, bulk 1970/201148
- Grigsby-Galt Papers, 1736/1982, bulk 1840/193048
- Office of the President. Lyon Gardiner Tyler Records, 1888/193548
- Virginia Counties Collection, 1600/2000, bulk 1730/189047
- James Washington Singleton Papers, 1770/1975, bulk 1850/192044
- Jim Comstock, Newspaper Editor and Collector, Papers, 1650/2003, bulk 1850/199543
- Oren F. Morton (1857-1926) Papers, 1799/192643
- William Carter Stubbs Papers (I), 1832/193643