- Philip S. Hench Walter Reed Yellow Fever collection, 1800/1998, bulk 1863/1974360
- Gregory A. Prince Mormon Studies Collection, 1813/2020298
- Papers of the Low Moor Iron Company
1873-1927241
- John L. Nau III Civil War History Collection, 1806/1988, bulk 1861/1865121
- Bondurant-Morrison Family Papers
1787-193680
- Duke family law firm papers, 1820/195976
- Duke Family Papers
1764-198361
- Aubrey E. Strode papers, 1861/196953
- Papers of Mark Twain
1862-1946, bulk 1872-191052
- W.E. Bibb Papers
1830-194040
- Blair family papers, 1821/194934
- Papers of Edward Price Buford, 1893/193129
- Randolph Huntington papers, 1860/190828
- James Whitcomb Riley Collection
1876-191227
- University of Virginia School of Nursing, 1819/201623