- Papers of Mark Twain
1862-1946, bulk 1872-1910154
- Papers of the Low Moor Iron Company
1873-1927149
- Philip S. Hench Walter Reed Yellow Fever collection, 1800/1998, bulk 1863/1974117
- Tyler Family Papers, Group D, 1939/195196
- Historical Photograph Collection, 1850/201089
- Edward "Teddy" Bolton Tucker Papers, 1760/2007, bulk 1800/190079
- Duke Family Papers
1764-198362
- Snyder Family papers, 1850/190146
- Monongalia County (W. Va.) Court Records and Miscellaneous Papers, 1774/195442
- W.E. Bibb Papers
1830-194036
- James Whitcomb Riley Collection
1876-191231
- Map Collection, 1629/199131
- Bailey-Law Collection, 1825/197130
- The Photographic Archive of Fairfax County, Virginia - The General Collection, c.1720-200727
- Topographic Maps, 1891/1989, bulk 1900/198025