- Abraham Lincoln Collection, 1860/19651
- Ackerly Family Papers7
- Administration records collection, 1776/197619
- Advertisement Trade Card for "Quignon-Rombach", 1880/19201
- African and African American photograph collection, 1850/19451
- Alan R. Shirkey photograph collection, 1877/19173
- Alexander Lockhart Nelson papers, 1848/19022
- Alexander Sterrett Paxton Papers, 1858/1959, bulk 1861/18652
- Alexander, Fultz, and Willson Families Collection, 1770/19701
- Alfred Leyburn Papers, 1823/1899, bulk 1830/18391
- Almanac collection, 1850/19092
- Alphin Family Photographs, 1870/19301
- Anderson Family papers, 1755/195814
- Ann Smith Academy Papers, 1807/19101
- Anne McClung Collection, 1844/19663