- S. B. Barham Account Book, 1896/19151
- S. Corder Musgrave Papers, 1891/19661
- S. F. (Bill) Royall, Jr. papers, 1883/19791
- S. Maria Elliott Family Collection, 1826/19421
- S.H. Cleveland Papers, 1887/19002
- Sabra Lucinda (Miner) Sturgiss Papers, 1838/19091
- Saint Andrew's Society collection, 1861/19956
- Salem School District, Board of Education, Record Books, 1888/19201
- Sallie Bennett Papers regarding World War I Flying Ace Louis Bennett, Jr., 1873/2009, bulk 1904/19264
- Salt Sulphur Springs Records, 1819/19321
- Salt Sulphur Springs Records, 1894/19041
- Sam Bowman Papers, 1848/19672
- Sam di Bonaventura papers, 1900/19984
- Sampson Snider Civil War Records and Other Material, 1864/19051
- Samuel A. Creelman Papers, 1861/19062