- 19th century newspaper illustrations collection, 1861/18943
- Alexander Haight family collection, 1764/197613
- C-SPAN records, 1809/2012, bulk 1978/20122
- C. Harrison Mann, Jr. map collection, 1579/19611
- C. Harrison Mann, Jr. papers, 1832/19792
- Carol R. Lubin papers, 1960/19811
- Charles Rodrigues playbill collection, 1879/20095
- Clark E. Warburton papers, 1920/197911
- Collis S. Hough Civil War letters to his wife Harriet Stevens Hough, 1861/18921
- Edward Vitale violin music collection, 1886/19511
- Edwin W. Lynch Vietnam War protest collection, 1965/19753
- Federal Theatre Project collection, 1885/1986, bulk 1935/19393
- George B. Holsinger photograph collection, 1860/19101
- George Mason University Student Government records, 1968/20191
- George Taylor Klipstein manuscript medical account books, 1881/19184