- Alexander Farish Robertson Papers, 1867/19311
- Bailey-Law Collection, 1825/19712
- Bell, Kent, Cloyd, Withrow Family Collection, 1780/19981
- Black, Kent, and Apperson Family Papers, 1779/19846
- Blacksburg Baptist Church Records, 1894/20071
- Charles Willis Cassell Family Papers, 1883/19502
- Dickson Family Papers, 1769/19244
- Dillard-Larkin Family Papers, 1809/19551
- Elden E. Billings Collection, 1862/19912
- Episcopal Diocese of Southwestern Virginia Records, 1866/2004, bulk 1919/19692
- Henry C. Wysor Family Papers, 1869/19182
- J. Hoge Tyler Family Collection, 1802/195620
- John Janney Papers,, 1811/1994, bulk 1840/18802
- Kent's Store Records, 1868/19471
- O'Shaughnessy Family Papers, 1857/19651