- Alexander Farish Robertson Papers, 1867/19313
- Ann A. Hertzler Collection, 1863/2013, bulk 1974/20001
- Bailey-Law Collection, 1825/19712
- Baughman Family Papers, 1837/19682
- Bell, Kent, Cloyd, Withrow Family Collection, 1780/19984
- Black, Kent, and Apperson Family Papers, 1779/19848
- Blake W. Corson, Jr., Papers, 1861/1984, bulk 1934/19791
- Buckhorn Coal Company Records, 1880/19611
- Chapman J. French Papers, 1903/19571
- Charles F. McKenna Collection, 1861/19982
- Charles W. Crush Collection, 1796/19783
- Charles Willis Cassell Family Papers, 1883/19501
- Civil War Small Manuscripts Collection, 1861/19961
- Clifford-Wysor Collection, 1852/19581
- Devota Pack Manuscript Collection, 1858/19772