- Gregory A. Prince Mormon Studies Collection, 1813/2020239
- John L. Nau III Civil War History Collection, 1806/1988, bulk 1861/1865141
- Philip S. Hench Walter Reed Yellow Fever collection, 1800/1998, bulk 1863/197491
- Bondurant-Morrison Family Papers
1787-193689
- Papers of the Low Moor Iron Company
1873-192768
- Duke Family Papers
1764-198354
- Duke family law firm papers, 1820/195950
- Randolph Huntington papers, 1860/190843
- Morton-Halsey family papers, 1833/195141
- Blair family papers, 1821/194935
- Wickham family papers, 1704/195028
- Gustavus Richard "Brown" Horner papers, 1820/189225
- University of Virginia School of Nursing, 1819/201623
- Papers of Mark Twain
1862-1946, bulk 1872-191022
- Christian S. Hutter miscellany, 1602/194521