- Anne Atkinson Chamberlayne Collection., 1742/19631
- Bugg Family Collection., 1876/19571
- Commencement Programs Collection, 1863/20211
- Dabney Lancaster and Lancaster Family Records, 1848/19741
- Dr. Wayne McWee Historical Newspapers, 1863/19621
- Harwood Family Collection, 1806/19831
- James Elliott Walmsley Collection, 1810/19391
- Katherine Courtenay Johnston Collection, 1829/19461
- Mattoon Family Collection, 1870/19661
- Paulett Family Business Records, 1877/19291
- Pi Gamma Mu Collection, 1818/19701
- Planters Bank President Portraits, 1870/19051
- Richard Couture Papers, 1860/20031
- Rosemary Sprague Collection, 1862/19911
- Ruffner Family Association Collection, 1811/2014, bulk 1999/20141