- Ann A. Hertzler Collection, 1863/2013, bulk 1974/20001
- Antoine Gaujot and Julien E. Gaujot Papers, 1840/19991
- Beattie Family University Memorabilia, 1875/19591
- Diploma Collection, 1877/19641
- Harry Downing Temple, Jr., Papers, 1872/2004, bulk 1930/20011
- Harvey Lee Price Papers, 1853/19491
- James I. Robertson Jr. Papers, 1849/20111
- Larry McBryde Collection on the John McLaren McBryde Family, 1859/20131
- Marshall W. Fishwick Collection, 1700/2007, bulk 1923/20071
- Ralph Minthorne Brown Papers, 1872/19471
- Records of the Virginia Cooperative Extension, 1862/19971
- Robert A. Belz Papers, 1869/19621
- Virginia Tech Corps of Cadets, Company A, Memorabilia, 1800/19701
- Wilhelmina Van Ingen Elarth Papers, 1862/19711