- Adele Goodman Clark papers, 1849/19781
- Admiral John Randolph Tucker Papers, 1865/18973
- Alexander Farish Robertson Papers, 1867/19311
- Alexander Haight family collection, 1764/19761
- Alumni Association Records, 1833/2014, bulk 1950/20051
- Ancella Bickley, Historian, Research Papers regarding African-Americans, 1775/2018, bulk 1970/20119
- Armistead Boothe Papers (MS164), 1803/19902
- Atkeson-Morgan Family Papers, 1833/1923, bulk 1850/19001
- Austin-Twyman Papers, 1765/193929
- Bailey-Law Collection, 1825/19712
- Bell, Kent, Cloyd, Withrow Family Collection, 1780/19981
- Benjamin A. Banks Papers, 1855/19741
- Black, Kent, and Apperson Family Papers, 1779/19845
- Blair family papers, 1821/19492
- Blow Family Papers, 1613/1960, bulk 1770/18757