- Dillard-Larkin Family Papers, 1809/19551
- Dr. Barbara Howe, Professor, Papers, 1856/2025, bulk 1964/20252
- Dr. Edward J. Van Liere Papers, 1890/19861
- Dudley and Rexrode Family Papers, 1873/20051
- Duke family law firm papers, 1820/19591
- Earl L. Core (1902-1984) Papers, 1756/19852
- Early Records of the Mount Vernon Ladies' Association, 1853/1951, bulk 1853/18753
- Edward "Teddy" Bolton Tucker Papers, 1760/2007, bulk 1800/19002
- Elden E. Billings Collection, 1862/19912
- Elizabeth Burger Jackson Collection, 1950/20061
- Eloise Word Skewis Papers, 1777/19074
- Emory L. Kemp Papers regarding Industrial History, 1735/20216
- Episcopal Diocese of Southwestern Virginia Records, 1866/2004, bulk 1919/19692
- Faris, Faris, and Stephens, Architects, Records, 1890/20131
- Geo. Gregory Smart collection of Washington and Mount Vernon ephemera, 1793/201714