- Alston Gordon Dayton Papers, 1846/19393
- American Missionary Society Papers, 1848/18821
- Ancella Bickley, Historian, Research Papers regarding African-Americans, 1775/2018, bulk 1970/201137
- Andrew Delmar Hopkins Papers, 1787/19431
- Andrew Nelson Campbell (d.1919) Papers, 1861/19121
- Andrew Nelson Campbell Papers, 1854/19281
- Andrew Nelson Campbell, Civil War Veteran and Monroe County Politician, Papers, 1856/19321
- Andrew S. Core, Typescripts and Charts, 1804/18881
- Anita Cutright Burnett, Collector, Papers, 1790/19351
- Anna Jarvis (1864-1948) Papers, 1858/19431
- Anna Jarvis (1864-1948) Papers, 1858/19581
- Anthony Ware, Miscellaneous Papers, 1773/18861
- Appalachian Prints Collection, 1839/2010, bulk 1859/190911
- Arah J. Evans Autograph Album, 1849/19531
- Archibald W. Campbell (1839-1899), Newspaperman, Papers, 1855/1941, bulk 1855/18993