- Booton-Modesitt Family Papers, 1809/1880, bulk 1820/18501
- Brown, Coalter, Tucker Papers (III), 1838/19641
- Buford Family Papers, 1845/18951
- C. W. Murdaugh Papers, 1853/18781
- Charles Campbell Papers, 1743/18961
- Fauntleroy Papers, 1831/19031
- George Michener Hart Collection on Moncure Robinson, 1816/19191
- Grigsby-Galt Papers, 1736/1982, bulk 1840/19301
- Hart Papers I and II, 1847/19341
- Ives Family Papers, 1850/19101
- John Alonzo Frenger Diary and Account Book, 1876/18791
- John W. Lewis and Lewis P. Olds Papers, 1808-1902, 1808/1902, bulk 1840/18791
- Manuscripts - People and Family Names, 1621/1949, bulk 18001
- Niebling and Duke family letters, 1847/19031
- Whittle-Greene Papers, 1855/19951