- Dabney Lancaster and Lancaster Family Records, 1848/19747
- Ruffner Family Association Collection, 1811/2014, bulk 1999/20144
- Anna E. Bass Collection, 1874/18753
- Bugg Family Collection., 1876/19573
- Rosemary Sprague Collection, 1862/19913
- Anne Atkinson Chamberlayne Collection., 1742/19632
- Commencement Programs Collection, 1863/20212
- Dr. Wayne McWee Historical Newspapers, 1863/19622
- Mattoon Family Collection, 1870/19662
- Pi Gamma Mu Collection, 1818/19702
- Elizabeth Burger Jackson Collection, 1950/20061
- Harwood Family Collection, 1806/19831
- James Elliott Walmsley Collection, 1810/19391
- Katherine Courtenay Johnston Collection, 1829/19461
- Paulett Family Business Records, 1877/19291