- A. Gold and Company ledgers, 1866/18801
- Abraham Lincoln Collection, 1860/19651
- Administration records collection, 1776/19761
- African and African American photograph collection, 1850/19451
- Alexander Lockhart Nelson papers, 1848/19021
- Alexander Sterrett Paxton Papers, 1858/1959, bulk 1861/18651
- Alexander, Fultz, and Willson Families Collection, 1770/19701
- Alfred Leyburn Papers, 1823/1899, bulk 1830/18391
- Almanac collection, 1850/19091
- Alphin Family Photographs, 1870/19301
- American Civil War collection, 1860/18951
- Anderson Family papers, 1755/19581
- Ann Smith Academy Papers, 1807/19101
- Anne McClung Collection, 1844/19661
- Baer Family Papers, 1744/19291