- Historical Photograph Collection, 1850/2010100
- Edward "Teddy" Bolton Tucker Papers, 1760/2007, bulk 1800/190079
- Tyler Family Papers, Group D, 1939/195176
- Monongalia County (W. Va.) Court Records and Miscellaneous Papers, 1774/195444
- Early Records of the Mount Vernon Ladies' Association, 1853/1951, bulk 1853/187530
- Duke Family Papers
1764-198329
- Snyder Family papers, 1850/190129
- Philip S. Hench Walter Reed Yellow Fever collection, 1800/1998, bulk 1863/197428
- Cocke Family Papers, 1725-193927
- Papers of Mark Twain
1862-1946, bulk 1872-191027
- John Tyler, Jr. Papers, 1800/192826
- Robert Waldsmith Collection of stereographs and cabinet cards, 1856/198124
- Sessional Records of South-Central Virginia Churches, 1760/199222
- Post Office Site Location Reports, 1837/195021
- Hampden-Sydney College Photograph Collection, 177520