- Alexander Farish Robertson Papers, 1867/19311
- Bailey-Law Collection, 1825/19712
- Black, Kent, and Apperson Family Papers, 1779/19845
- Dickson Family Papers, 1769/19245
- Elden E. Billings Collection, 1862/19912
- Episcopal Diocese of Southwestern Virginia Records, 1866/2004, bulk 1919/19691
- J. Hoge Tyler Family Collection, 1802/195612
- James W. M. Harris Papers, 1857/19001
- John Janney Papers,, 1811/1994, bulk 1840/18805
- Nelson Family Papers, 1783/18721
- Robert Selph Henry Papers, 1861/19712
- Rosanna Croy Dawson Collection, 1847/19072
- Susana Torre Architectural Collection, 1830/2003, bulk 1967/20031
- Turner Family Papers, 1830/19441
- Wharton and Radford Families Papers, 1783/19067