- Siler Family Papers, 1848/19681,147
- Robert E. Lee Family papers, 1792/1935, bulk 1833/1870485
- John L. Nau III Civil War History Collection, 1806/1988, bulk 1861/1865273
- Roy Bird Cook (1886-1961), Collector, Papers, 1679/1984, bulk 1840/1960147
- Monongalia County (W. Va.) Court Records and Miscellaneous Papers, 1774/1954145
- Sheet Music Collection, 1827/1974138
- Emory L. Kemp Papers regarding Industrial History, 1735/2021129
- Gregory A. Prince Mormon Studies Collection, 1813/2020122
- Cocke Family Papers, 1725-1939114
- Early Records of the Mount Vernon Ladies' Association, 1853/1951, bulk 1853/1875114
- Edward "Teddy" Bolton Tucker Papers, 1760/2007, bulk 1800/1900110
- Historical Photograph Collection, 1850/2010106
- Restoration Files for the Historic Structures Report, 1750/2005105
- Galt Papers (III), 1750/1991103
- Ohio County (W. Va.) Court Records and Miscellaneous Papers, 1772/1954, bulk 1777/1930101