- T.B. Camden Papers, 1862/19071
- Tabb Family Papers, 1797/18754
- Talbott-Tolbert Family Papers, 1784/19311
- Taliaferro Family Papers, 1846/18953
- Tasker Howard Bliss Correspondence, 1841/19091
- Tate Thompson Brady Family papers, 1785/20058
- Taylor County Inns, Ledger Books, 1757/18871
- Taylor collection of Lewis family papers, 1700/19501
- Tazewell Family Papers, 1838/1978, bulk 1860/18703
- Tazewell Taylor Papers, 1784/18733
- Temple Family Papers, 1845/18711
- Terrill-Porterfield Families, Papers regarding the Civil War and Other Material, 1716/1994, bulk 1840/19201
- Terry Dinsmore, Collector, Cast Iron Tools, 1840/18901
- Thaddeus S. Harris account books, 1855/18682
- The Cox-McPherson Ledgers and Papers
1758-1949 Inclusive1