- John L. Nau III Civil War History Collection, 1806/1988, bulk 1861/18654,641
- Siler Family Papers, 1848/19681,146
- Robert E. Lee Family papers, 1792/1935, bulk 1833/1870316
- Union Volunteers of West Virginia Regiments, Civil War Service Records, 1861/1865262
- Cocke Family Papers,
1725-1939141
- Roy Bird Cook (1886-1961), Collector, Papers, 1679/1984, bulk 1840/1960141
- Sheet Music Collection, 1827/1974139
- Monongalia County (W. Va.) Court Records and Miscellaneous Papers, 1774/1954137
- Emory L. Kemp Papers regarding Industrial History, 1735/2021128
- Gregory A. Prince Mormon Studies Collection, 1813/2020120
- Early Records of the Mount Vernon Ladies' Association, 1853/1951, bulk 1853/1875116
- Edward "Teddy" Bolton Tucker Papers, 1760/2007, bulk 1800/1900108
- James I. Robertson Jr. Papers, 1849/2011107
- Ohio County (W. Va.) Court Records and Miscellaneous Papers, 1772/1954, bulk 1777/1930105
- Restoration Files for the Historic Structures Report, 1750/2005105