- Alfred R. Gibbons letter, 18631
- Alfred Spates Papers
1843-19096
- Alice and Phoebe Cary Collection
1858-18901
- Allen-Kean-Laurence family letters, 1837/19601
- American Civil War collection, 1860/189520
- Andrew C. L. Gatewood papers, 1860/19932
- Andrew J. McCoy Civil War letters, 1863/18641
- Andrew Jackson Davis Collection2
- Andrew Jackson Davis Collection, 1840/20112
- Ann A. Hertzler Collection, 1863/2013, bulk 1974/20001
- Anson Du Puy Van Buren letters, 1863/19971
- Appalachian Prints Collection, 1839/2010, bulk 1859/19093
- Armistead-Cocke Papers, 1680/19179
- Atkeson-Morgan Family Papers, 1833/1923, bulk 1850/19002
- Augustus C. Golding Papers, 1859/1934, bulk 1862/18646