- African American Stereoview Collection, 1860/19011
- Alabama Collection, 1823/18932
- Alexander Brown Papers (I), 1815/191016
- Alexander Brown Papers (II), 1748/19008
- Alexander Family Papers, 1860/18671
- Alexander Hamilton, Jr. Letters, 1832/18331
- Alexander M. Davis Papers, 1850/18924
- Alice Hermione Wheaton Literature Journal, 1860/18802
- Allen-Kean-Laurence family letters, 1837/19602
- Alumni Association Records, 1833/2014, bulk 1950/20055
- Ambrose Hite Papers, 1861/18632
- Amelia County, Va. Merchant's Account Book, 1852/1903, bulk 1852/18562
- Amos Johnson Ledgers, 1808/1861, bulk 1808/18211
- Amos Koontz Papers I, 1809/1965, bulk 1936/19652
- Andrew J. Weeks Papers, 1861/1902, bulk 1862/18662