- Anna Maria Hickman Otis Mead Chalmers family papers, 1821/189724
- Anne Atkinson Chamberlayne Collection., 1742/19631
- Anne McClung Collection, 1844/19662
- Annual and special reports of the Superintendent, 1840/19941
- Anthony Ware, Miscellaneous Papers, 1773/18861
- Antoine Gaujot and Julien E. Gaujot Papers, 1840/19992
- Antonia Ford letters, 1855/18592
- Appalachian Prints Collection, 1839/2010, bulk 1859/190949
- Appomattox Manor Music Collection, 1800/1940, bulk 1850/19101
- Arah J. Evans Autograph Album, 1849/19531
- Archibald W. Campbell (1839-1899), Newspaperman, Papers, 1855/1941, bulk 1855/18993
- Aretas Brooks Fleming (1839-1923) Papers, 1784/19241
- Aretas Brooks Fleming Papers, 1784/19241
- Armistead Boothe Papers (MS164), 1803/199012
- Armistead Papers, 1736/18971