- Ackerly Family Papers4
- Administration records collection, 1776/197612
- African and African American photograph collection, 1850/19451
- Alexander Lockhart Nelson papers, 1848/19021
- Alexander Sterrett Paxton Papers, 1858/1959, bulk 1861/18652
- Alexander, Fultz, and Willson Families Collection, 1770/19701
- Alfred Leyburn Papers, 1823/1899, bulk 1830/18391
- Almanac collection, 1850/19092
- Anderson Family papers, 1755/195823
- Ann Smith Academy Papers, 1807/19101
- Anne McClung Collection, 1844/19662
- Baer Family Papers, 1744/19291
- Bank of Rockbridge Currency and Lexington Lottery Ticket collection, 1803/18622
- Barbara Cary Johnston Willard Scrapbook, 1800/20061
- Ben Benson Collection, 1789/20151