- Account Books, 1782/18952
- Ackerly Family Papers4
- Adele Goodman Clark papers, 1849/19781
- Alexander Brown Papers (I), 1815/19103
- Alexander Family Papers
1800-18909
- Alexander Von Humboldt Portrait Print, 1855/18901
- Alexandria Black Family Reunion Digital Collection, 1937/20051
- Alfred Spates Papers
1843-19093
- Allen-Kean-Laurence family letters, 1837/19601
- Ann Sophia Stephens Collection
1836-18841
- Appalachian Prints Collection, 1839/2010, bulk 1859/19091
- Archibald M. Fauntleroy papers, 18571
- Armistead-Cocke Papers, 1680/19174
- Atkeson-Morgan Family Papers, 1833/1923, bulk 1850/19002
- Austin-Twyman Papers, 1765/193911