- Cocke Family Papers, 1725-1939234
- Carter Family Papers, 1667/1862, bulk 1792/1861112
- Edward "Teddy" Bolton Tucker Papers, 1760/2007, bulk 1800/190079
- Tyler Family Papers, Group D, 1939/195162
- Monongalia County (W. Va.) Court Records and Miscellaneous Papers, 1774/195449
- Early Records of the Mount Vernon Ladies' Association, 1853/1951, bulk 1853/187537
- Webb-Prentis Family Papers
1770-190836
- Merritt Family Papers, 1780/190934
- Haymond Family Papers, 1783/1867, bulk 1825/186732
- West Virginia Land Grants Records, 1748/191232
- Snyder Family papers, 1850/190130
- Tyler Family Papers, Group A, 1716/194629
- David Hunter Strother, Artist, Artwork and Papers, 1744/1996, bulk 1833/188727
- Maupin-Washington Papers, 1732/193225
- Papers of Creed Taylor
1791-187325