- Blacksburg [Virginia] Presbyterian Church Land Deeds, 1850/19242
- Bobbitt Family Papers, 1825/19514
- Bristol-Moore Stamp Kit, 1854/18632
- Brotherton Family Collection, 1854/18877
- Brown Family Papers, 1825/1965, bulk 1850/189432
- Charles A. Miller Family Papers, 1708/19263
- Charles W. Crush Collection, 1796/19783
- Charles W. Hardin Collection, 1847/18832
- Charles Woodson Collection, 1814/18612
- Charlton Family Papers, 1853/19582
- Clifford-Wysor Collection, 1852/19584
- Crowder Family Papers,, 1821/18751
- Curry Family Letters, 1851/18812
- Daniel Bedinger Lucas Papers, 1812/18241
- Dickson Family Papers, 1769/192412