- Board of Trustees records, 1774/19668
- Brady Family Papers, 1750/19801
- Breckinridge Family Papers, 1850/18831
- Brooks Family Papers, 1841/18841
- Campbell Family Papers, 1843/19503
- Carleton Family Collection, 1830/19501
- Christopher A. Dorrance collection, 1750/20001
- Collection of U. S. House of Representatives printed documents about prohibition, 1808/19301
- Construction Proposal and Engineer's Report for the North River Navigation Company, 1850/18571
- Cralle and Hurt Family Papers, 1801/20053
- Davidson Family Papers, 1830/19154
- Dillon Family Papers, 1805/19445
- Dr. William S. Plumer manuscripts, 1841/18672
- Dunlap Family Papers, 1830/18784
- Ebenezer Dickey Junkin Scrapbook, 1853/18561