- S. Bank Kiles Book and Letter, 1847/18591
- S. Maria Elliott Family Collection, 1826/19421
- Sabra Lucinda (Miner) Sturgiss Papers, 1838/19091
- Sailing Ship Advertisement Cards, 18501
- Saint Andrew's Society collection, 1861/19952
- Salt Sulphur Springs Records, 1819/19321
- Salt Sulphur Springs Records, 1825/18831
- Sam Bowman Papers, 1848/19672
- Samuel B. Finley Account Books, 1802/18593
- Samuel D. Morton and Co. Account Books, 1826/18914
- Samuel Davidson Family Papers, 1823/19395
- Samuel E. Smith record book, 1818/18502
- Samuel F. Bright account books, 1826/18611
- Samuel G. Clark Liberty Iron Furnace Collection, 1809/19172
- Samuel H. Yonge papers, 1890/19351