- Austin-Twyman Papers, 1765/193947
- Carter Family Papers, 1667/1862, bulk 1792/186135
- Wharton and Radford Families Papers, 1783/190611
- Robert Morton Hughes Papers, 1754/195010
- Manuscripts - Geographic Names, Business Names and Subjects, 1725/19499
- Cazenove Family Papers (MS212), 1786/19707
- James Washington Singleton Papers, 1770/1975, bulk 1850/19207
- Ancella Bickley, Historian, Research Papers regarding African-Americans, 1775/2018, bulk 1970/20116
- Brown, Coalter, Tucker Papers (I), 1790/19296
- Emory L. Kemp Papers regarding Industrial History, 1735/20216
- Webb Family Papers, 1790/19756
- Black, Kent, and Apperson Family Papers, 1779/19845
- Geo. Gregory Smart collection of Washington and Mount Vernon ephemera, 1793/20175
- Peter family papers, 1722/19325
- Jerdone Family papers, 1753/18904