- Amos Johnson Ledgers, 1808/1861, bulk 1808/18211
- Amos Koontz Papers I, 1809/1965, bulk 1936/19652
- Ancella Bickley, Historian, Research Papers regarding African-Americans, 1775/2018, bulk 1970/201118
- Anderson Family papers, 1755/195820
- Andrew Delmar Hopkins Papers, 1787/19431
- Andrew Jackson Davis Collection, 1840/20113
- Andrew S. Core, Typescripts and Charts, 1804/18881
- Anita Cutright Burnett, Collector, Papers, 1790/19351
- Ann Lettice Murdoch diary, 1841/18641
- Ann Smith Academy Papers, 1807/19101
- Anna Burton Ellett Collection, 1751/19321
- Anna Maria Hickman Otis Mead Chalmers family papers, 1821/189724
- Anne Atkinson Chamberlayne Collection., 1742/19631
- Anne Hulme Diary, 1838/18502
- Anne McClung Collection, 1844/19661