- Abner Johnson Leavenworth Papers, 1825/18612
- Alexander Brown Papers (I), 1815/19102
- Allen-Kean-Laurence family letters, 1837/19601
- Austin-Twyman Papers, 1765/19396
- Barnes Family Papers, 1797/1926, bulk 1818/18752
- Baytop-Fitzhugh Papers, 1840/18661
- Benjamin Stoddert Ewell Papers, 1784/1934, bulk 1830/189219
- Blair, Banister, Braxton, Horner, Whiting Papers, 1760/1890, bulk 1765/18172
- Booton-Modesitt Family Papers, 1809/1880, bulk 1820/185013
- Borland Family Papers, 1771/19405
- Bound Music Collection, 1800/197021
- Bruton Parish Church (Williamsburg, Va.) records, 1662/2010, bulk 1900/20001
- Cabell Family Papers, 1693/1913, bulk 1743/18231
- Campbell Family Papers, 1726/192020
- Carter Family Papers, 1667/1862, bulk 1792/1861100