- Administration records collection, 1776/19765
- Anderson Family papers, 1755/195823
- Bank of Rockbridge Currency and Lexington Lottery Ticket collection, 1803/18621
- Board of Trustees records, 1774/19666
- Campbell Family Papers, 1843/19501
- Cralle and Hurt Family Papers, 1801/20051
- Davidson Family Papers, 1830/19151
- Dillon Family Papers, 1805/19442
- Dr. William S. Plumer manuscripts, 1841/18671
- Dunlap Family Papers, 1830/18783
- Elisha Franklin Paxton papers, 1808/1981, bulk 1853/18632
- Fix Family Papers, 1830/19241
- Francis Wilkinson Pickens collection, 1826/18651
- Franklin Society records, 1801/18919
- George A. Baxter Family papers, 1797/191818