- A. E. Dick Howard papers, 1928/20171
- Albert Frederick Wilson papers, 1840/19341
- Albert R. Gallatin papers, 1795/18281
- Alderman family papers, 1779/19615
- Anna Maria Hickman Otis Mead Chalmers family papers, 1821/189714
- Armstead L. Robinson papers, 1848/2001, bulk 1967/19921
- Aubrey E. Strode papers, 1861/19691
- B.H. Winston report card, 1844/18451
- Beverley R. Tucker papers, 1886/19731
- Blair family papers, 1821/19492
- Burnley Family papers, 1808/19643
- Caperton family genealogical research files, 1938/19801
- Carter Glass Papers, 1820/19461
- Celestia "Essie" Wade Butler Smith papers, 1793/20022
- Christian S. Hutter miscellany, 1602/194532