- Inge Horton Architectural Collection, 1964/19991
- Institute for the History of Technology and Industrial Archaeology Records, 1875/2005, bulk 1980/20058
- International Association for Identification Records, 1842/2012, bulk 1910/19594
- Invoice from George W. Caperton, 18442
- Ira E. Robinson Papers, 1818/19301
- Irvine-Saunders Family Papers
1745-1910 Inclusive7
- Isaac & Josiah Williams Brick Company, Account Books, 1844/19901
- Isaac Ambler Papers, 1828/18601
- Isaac B. Smith, Farmer and Music Teacher, Newspaper Clippings and Other Material, 1840/19841
- Isaac Campbell Account Book, 1834/18632
- Isaac Caruthers, Monroe County Merchant, Store and Tavern Ledgers, 1819/18631
- Isaac Horne Ledgers, 1824/18703
- Isabella Furnace Account Book (Page County, Va.), 1827/18542